Adipogenesis: forces that tip the scales

作者：MacDougald OA^*; Mandrup S

来源：Trends in Endocrinology and Metabolism, 2002, 13(1): 5-11.

DOI：10.1016/S1043-2760(01)00517-3

The balance of contradictory signals experienced by preadipocytes influences fat must be maintained within a relatively narrow whether these cells undergo adipogenesis. In addition to the endocrine system, range to maximize health. these signals originate from the preadipocytes themselves or operate as part of a feedback loop involving mature adipocytes. The factors that regulate The process of adipogenesis adipogenesis either promote or block the cascade of transcription factors that coordinate the differentiation process. Some of the positive factors reviewed include insulin-like growth factor I, macrophage colony-stimulating factor, fatty acids, prostaglandins and glucocorticoids, and negative factors reviewed include Wnt, transforming growth factor beta, inflammatory cytokines and prostaglandin F-2alpha. Tipping the scales towards or away from adipogenesis has profound implications for human health. In this review, we describe recent contributions to the field and will focus an factors that probably play a role in vivo.

• 出版日期2002-2