Application of biomaterials for the detection of amyloid aggregates

作者:Zako Tamotsu*; Maeda Mizuo
来源:Biomaterials Science, 2014, 2(7): 951-955.
DOI:10.1039/c4bm00026a

摘要

Amyloid aggregates, which include oligomers and fibrils, are considered to cause various diseases, and their detection is important. In this minireview, recent developments on biomaterials, such as proteins, nanoparticles, and chemical reagents, for detecting amyloid aggregates are discussed. In particular, the molecular chaperone prefoldin (PFD) exhibits interesting properties for the interaction and detection of amyloid oligomers. In fact, any molecule that can bind amyloid aggregates could be useful for their detection.

  • 出版日期2014
  • 单位RIKEN