Anterior chamber interleukin 1 beta, interleukin 6 and prostaglandin E-2 in patients undergoing femtosecond laser-assisted cataract surgery

作者：Wang, Li; Zhang, Zhe; Koch, Douglas D.; Jia, Yading; Cao, Weifang; Zhang, Suhua^*

来源：British Journal of Ophthalmology, 2016, 100(4): 579-582.

DOI：10.1136/bjophthalmol-2015-307586

• EPITHELIAL-CELLS
• TEAR FLUID
• TNF-ALPHA
• INFLAMMATION
• CONJUNCTIVA
• EXPRESSION
• IL-1-BETA
• DISEASE

Purpose To evaluate the interleukin (IL) 1 beta, IL-6 and prostaglandin E-2 (PGE(2)) concentrations in aqueous humour in patients undergoing femtosecond laserassisted cataract surgery.
Methods In 27 eyes of 27 patients undergoing femtosecond laser-assisted cataract surgery (femto group), aqueous humour of 100 mu L was collected after laser treatment. In 15 eyes of 15 subjects undergoing routine cataract surgery (control group), aqueous humour of 100 mu L was also collected. The IL-1 beta, IL-6 and Prostaglandin E2 (Human Interleukin 1 beta, Interleukin 6 and Prostaglandin E2 ELISA Kits, Bio-Swamp Life Science) were used to determine the concentrations of IL-1 beta, IL-6 and PGE2 in the aqueous humour. All patients were treated with non-steroidal anti-inflammatory drugs prior to surgery.
cResults For IL-1 beta, IL-6 and PGE2, respectively, the mean concentration values in aqueous humour were 25.6, 24.6 and 64.2 pg/mL in the femto group, and 17.1, 15.2 and 45.7 pg/mL in the control group (table 2). Concentrations of IL-1 beta, IL-6 and PGE2 were significantly higher in the femto group than those in the control group (all p< 0.01). There were no significant correlations between concentrations of IL-1 alpha, IL-6 or PGE2 and age, cataract densities, suction time or laser time (all p> 0.05).
Conclusions Inflammatory cytokines IL-1 alpha, IL-6 and PGE2 significantly increased after femtosecond laserassisted cataract surgery, which maybe the cause of intraoperative miosis seen in these patients.

• 出版日期2016-4
• 单位山西省眼科医院; 天津医科大学