Steric Control of Site Selectivity in the Pd-Catalyzed C-H Acetoxylation of Simple Arenes

作者：Cook Amanda K; Emmert Marion H; Sanford Melanie S^*

来源：Organic Letters, 2013, 15(21): 5428-5431.

DOI：10.1021/ol4024248

This report describes the use of an oxidant and a ligand to control site selectivity in the Pd(OAc)(2)-catalyzed C-H acetoxylation of simple arenes. The use of Mesl(OAc)(2) as the terminal oxidant in combination with acridine as the ligand results in primarily sterically controlled selectivity. In contrast, with Pd(OAc)(2) as the catalyst and Phl(OAc)(2) as the oxidant, electronic effects dominate the selectivity of arene C-H acetoxylation.

• 出版日期2013-11-1