A new synthetic methodology for the preparation of biocompatible and organo-soluble barbituric- and thiobarbituric acid based chitosan derivatives for biomedical applications

作者：Shahzad Sohail; Shahzadi Lubna; Mahmood Nasir; Siddiqi Saadat Anwar; Rauf Abdul; Manzoor Faisal; Chaudhry Aqif Anwar; Rehman Ihtesham Ur; Yar Muhammad^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2016, 66: 156-163.

DOI：10.1016/j.msec.2016.04.056

• Chitosan derivatives
• Organo-soluble
• Synthetic method
• Vero cells
• Triethylorthoformate

Chitosan's poor solubility especially in organic solvents limits its use with other organo-soluble polymers; however such combinations are highly required to tailor their properties for specific biomedical applications. This paper describes the development of a new synthetic methodology for the synthesis of organo-soluble chitosan derivatives. These derivatives were synthesized from chitosan (CS), triethyl orthoformate and barbituric or thiobarbituric acid in the presence of 2-butannol. The chemical interactions and new functional motifs in the synthesized CS derivatives were evaluated by FTIR, DSC/TGA, UV/VIS, XRD and H-1 NMR spectroscopy. A cytotoxicity investigation for these materials was performed by cell culture method using VERO cell line and all the synthesized derivatives were found to be non-toxic. The solubility analysis showed that these derivatives were readily soluble inorganic solvents including DMSO and DMF. Their potential to use with organo-soluble commercially available polymers was exploited by electrospinning; the synthesized derivatives in combination with polycaprolactone delivered nanofibrous membranes.

• 出版日期2016-9-1