Complementary Effects of Multivitamin and Omega-3 Fatty Acid Supplementation on Indices of Cardiovascular Health in Individuals with Elevated Homocysteine

作者：Earnest Conrad P^*; Kupper Jennifer S; Thompson Angela M; Guo Weimin; Church Timothy S

来源：International Journal for Vitamin and Nutrition Research, 2012, 82(1): 41-52.

DOI：10.1024/0300-9831/a000093

• homocysteine
• omega-3 fatty acid
• vitamin
• nutritional supplement
• C-reactive protein

Homocysteine (HCY), C-reactive protein (hsCRP), and triglycerides (TG) are risk factors for cardiovascular disease (CVD). While multivitamins (MVit) may reduce HCY and hsCRP, omega-3 fatty acids (N3) reduce TG; yet, they are seldom studied simultaneously. We randomly assigned 100 participants with baseline HCY (%26gt; 8.0 umol/L) to the daily ingestion of: (1) placebo, (2) MVit (VitC: 200 mg; VitE: 400 IU; VitB6: 25 mg; Folic Acid: 400 ug; VitB12: 400 ug) + placebo, (3) N3 (2 g N3, 760 mg EPA, 440 mg DHA) + placebo, or (4) MVit + N3 for 12 weeks. At follow-up, we observed significant reductions in HCY (umol/L) for the MVit (-1.43, 95 %CI, -2.39, -0.47) and MVit + N3 groups (-1.01, 95 %CI, -1.98, -0.04) groups, both being significant (p %26lt; 0.05) vs. placebo (-0.57, 95 %CI, -1.49,0.35) and N3 (1.11, 95 % CI, 0.07, 2.17). hsCRP (nmol/L) was significantly reduced in the MVit (-6.00, 95 %CI, -1.04, -0.15) and MVit + N3 (-0.98, 95 %CI, -1.51, -0.46) groups, but not vs. placebo (-0.15, 95 %CI, -0.74,0.43) or N3 (-0.53,95 %CI, -1.18, 0.12). Lastly, we observed significant reductions in TG for the N3 (-0.41, 95 %CI, -0.69, -0.13) and MVit + N3 (-0.71, 95 %CI, -0.93, -0.46) groups, both significant vs. placebo (-0.10, 95 %CI, -0.36, 0.17) and MVit groups (0.15, 95 %CI, -12, 0.42). The co-ingestion of MVit + N3 provides synergistic affects on HCY, hsCRP, and plasma TG.

• 出版日期2012-2