The relationships among hemostatic markers, the withdrawal of fondaparinux due to a reduction in hemoglobin and deep vein thrombosis in Japanese patients undergoing major orthopedic surgery

作者：Hasegawa Masahiro; Wada Hideo^*; Wakabayashi Hiroki; Yoshida Kakunoshin; Miyamoto Noriki; Asanuma Kunihiro; Matsumoto Takeshi; Ohishi Kohshi; Shimokariya Yuji; Yamada Norikazu; Uchida Atsumasa; Sudo Akihiro

来源：Clinica Chimica Acta, 2013, 425: 109-113.

DOI：10.1016/j.cca.2013.07.009

• Deep vein thrombosis (DVT)
• Anti-Xa activity
• Fondaparinux
• Orthopedic surgery
• Withdrawal

Background: The relationships among the hemostatic markers, the development of deep vein thrombosis (DVT) and the withdrawal of fondaparinux due to a reduction in the hemoglobin levels were examined. %26lt;br%26gt;Methods: Two-hundred twenty-one Japanese patients who underwent major orthopedic surgery and were treated with 1.5 mg of fondaparinux instead of 2.5 mg of fondaparinux were studied. Forty-seven of 221 patients discontinued fondaparinux treatment (withdrawal group) and 37 patients developed DVT. %26lt;br%26gt;Results: The age, frequency of total knee arthroplasty (TKA), withdrawal of fondaparinux, reduction of hemoglobin and the plasma levels of soluble fibrin (SF), D-dimer and fibrinogen and fibrin degradation product (FDP) on day 1 after the operation were significantly higher in the patients with DVT. Elevated SF, D-dimer or FOP levels were associated with the risk for DVT. The age, frequency of TKA or DVT, anti-Xa activity and the creatinine, FDP and D-dimer levels were significantly higher in the withdrawal group. An anti-Xa level %26gt;0.33 mg/l and an elevated D-dimer or FOP level were associated with the risk of withdrawal. %26lt;br%26gt;Conclusion: The age and SF levels, TKA and withdrawal of fondaparinux were related to the risk of DVT, and the anti-Xa activity, creatinine level and DVT were related to the risk of withdrawal of fondaparinux due to a reduction in hemoglobin.

• 出版日期2013-10-21