A novel combination of mild electrical stimulation and hyperthermia: General concepts and applications

作者：Kai Hirofumi^*; Suico Mary Ann; Morino Saori; Kondo Tatsuya; Oba Mariko; Noguchi Mikiko; Shuto Tsuyoshi; Araki Eiichi

来源：International Journal of Hyperthermia, 2009, 25(8): 655-660.

DOI：10.3109/02656730903039605

• hyperthermia
• mild electrical stimulation
• low-intensity current
• heat shock
• Hsp72

This review discusses the basic concepts, effects and applications of hyperthermia and mild electrical stimulation (MES) using low-intensity direct current. It also proposes a novel combinatorial use of MES and hyperthermia, and briefly outlines the rationale and the effects of MES and hyperthermia combination treatment on certain diseases (diabetes, hepatic ischaemia/reperfusion injury and gastric ulcer). The integrated modalities of MES and hyperthermia might find therapeutic applications to stress-induced diseases and intractable diseases of dysregulated signalling pathways.

• 出版日期2009