A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer

作者：Yang, Jing; Li, Sainan; Li, Jingjing; Wang, Fan; Chen, Kan; Zheng, Yuanyuan; Wang, Jianrong; Lu, Wenxia; Zhou, Yuqing; Yin, Qin; Zhang, Huawei; Guo, Chuanyong^*

来源：Pancreatology, 2016, 16(4): 605-614.

DOI：10.1016/j.pan.2016.04.033

• Diagnostic accuracy
• K-ras mutations
• Meta-analysis
• Pancreatic cancer
• Pancreatic juice
• Molecular marker

Background: K-ras codon 12 mutation is one of the earliest genetic changes in the development of pancreatic cancer (PC) and accurate detection of K-ras mutations is gaining increasing attention in the field of molecular diagnosis. @@@ Methods: Original research articles which evaluated the diagnostic accuracy of K-ras mutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic curve analysis was used to summarize the overall test performance. @@@ Results: We assessed 16 studies from 15 published articles. The pooled sensitivity and specificity were 59% (95%CI: 54%-64%) and 87% (95%CI: 84%-89%), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.13 (95%CI: 2.73-6.25) and 0.42 (95%CI: 0.32-0.56), respectively, and the pooled diagnostic odds ratio was 13.66 (95% CI: 7.25-25.74). @@@ Conclusions: Our results indicate that the analysis of K-ras mutations in pancreatic juice has a considerable diagnostic value in PC. Further studies with rigorous design, large sample size, and multi-regional co-operation are needed.

• 出版日期2016-7
• 单位同济大学; 南京医科大学; 苏州大学