Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair

作者：Ardelt Agnieszka A^*; Bhattacharyya Bula J; Belmadani Abdelhak; Ren Dongun; Miller Richard J

来源：Experimental Neurology, 2013, 248: 246-253.

DOI：10.1016/j.expneurol.2013.06.017

• Animal models
• Brain ischemia
• Chemokines
• Electrophysiology
• Neuroregeneration

In response to ischemic injury, the brain mounts a repair process involving the development of new neurons, oligodendrocytes, and astrocytes. However, the manner in which new neurons integrate into existing brain circuitry is not well understood. Here we observed that during the four weeks after transient middle cerebral artery occlusion (MCAO), doublecortin (DCX)-expressing neural progenitors originating in the subventricular zone (SVZ) were present in the ischemic lesion borderzone, where they received gamma-aminobutyric acid (GABA) inputs, a feature that is common to newly developing neurons. The chemokine stromal derived factor-1 (SDF-1 or CXCL12) was enriched in lesional endothelial and microglial cells for up to four weeks after transient MCAO, and application of SDF-1 to acute brain slices enhanced GABAergic inputs to the new neurons. These observations suggest that SDF-1 is in a position to coordinate neovascularization and neurogenesis during the repair process after cerebral ischemia-reperfusion.

• 出版日期2013-10
• 单位西北大学