Antibacterial and Membrane-damaging Activities of Rosmarinic Acid against Pathogenic Organisms of Acne

作者：Hu, Dong-Pei^*; Zhao, Jun-Ru; Gu, Yun-Zhi; Xu, Hong-Xi; Li, Xiao-Qian

来源：Latin American Journal of Pharmacy, 2015, 34(9): 1866-1870.

• membrane-damaging activity
• rosmarinic acid
• Staphylococcus aureus
• Staphylococcus epidermidis
• Propionibacterium acnes

The aim of this study was to test whether rosmarinic acid (RA) exerts antibacterial activity on pathogenic organisms of acne via its membrane-damaging effect. The MICs and the bacteriostatic effect of RA on Staphylococcus aureus, S. epidermidis and Propionibacterium acnes were measured. Meanwhile, the membrane-damaging effect was observed by determining the permeability of the cell membrane and cell wall, the release of the liposome-entrapped, and the ion leakage of S. aureus. Our data indicate that RA possessed bactericidal activity that depends mainly on its ability to induce membrane-damaging. Moreover, the bactericidal action of RA proven in this study suggests that RA may serve as a prototype for the development of anti-infective agents targeting pathogenic organisms of acne.

• 出版日期2015-11
• 单位上海中医药大学