Age-dependent increase in the expression of antioxidant-like protein-1 in the gerbil hippocampus

作者:Park Jin A; Park Joon Ha; Ahn Ji Hyeon; Kim Jong Dai; Won Moo Ho; Lee Choong Hyun
来源:Molecular Medicine Reports, 2016, 14(4): 3215-3219.
DOI:10.3892/mmr.2016.5619

摘要

Antioxidant-like protein-1 (AOP-1) reduces the intracellular level of reactive oxygen species. In the present study, the age-related change in AOP-1 expression in the hippocampus among young, adult and aged gerbils was compared using western blot analysis and immunohistochemistry. The results demonstrated that the protein expression of AOP-1 was gradually and significantly increased in the hippocampus during the normal aging process. In addition, the age-dependent increase in AOP-1 immunoreactivity was also observed in pyramidal neurons of the hippocampus proper; however, in the dentate gyrus, AOP-1 immunoreactivity was not altered during the normal aging process. These results indicated that the expression of AOP-1 is significantly increased in the hippocampus proper, but not in the dentate gyrus, during the normal aging process.

  • 出版日期2016-10