Dose-Dependent Development of Depressive Symptoms During Adjuvant Interferon-alpha Treatment of Patients With Malignant Melanoma

作者：Friebe Astrid^*; Horn Martin; Schmidt Folkhart; Janssen Gesa; Schmid Wendtner Monika H; Volkenandt Matthias; Hauschild Axel; Goldsmith Charlie H; Schaefer Martin

来源：Psychosomatics, 2010, 51(6): 466-473.

Background: Adjuvant IFN-alpha treatment for patients with malignant melanoma is often complicated by depression. The influence of dosage, however, is unknown. Objective: The authors sought to elucidate this dosage effect. Method: Using the Zung Self-Rating Depression Scale and the German Bf-S Self-Rating (Affectivity) Scale, the authors prospectively compared the frequency and severity of IFN-alpha-induced depressive symptoms between a group of 29 patients receiving low-dose and 17 patients getting high-dose induction therapy for 4 weeks. Results: Patients receiving high-dose induction treatment had significantly higher depression scores after 4 weeks, and significantly more patients in the high-dose group developed depression. Conclusion: The authors concluded that frequency and severity of IFN-alpha-associated depression during melanoma treatment are dose-dependent. (Psychosomatics 2010; 51:466-473)

• 出版日期2010-12