Asymmetric synthesis of poly-substituted spirocyclohexane oxindole via a squaramide catalyzed cascade Michael-Michael-aldol sequence

作者：Sun Qiang Sheng^*; Chen Xiao Yang; Zhu Hua; Lin Hua; Sun Xing Wen; Lin Guo Qiang

来源：Organic Chemistry Frontiers, 2015, 2(2): 110-113.

DOI：10.1039/c4qo00299g

A squaramide-catalyzed Michael-Michael-aldol cascade sequence of three readily accessible substrates (1,3-dicarbonyl compound, nitroalkene and methyleneindolinone) was developed. The reactions led to a series of enantioenriched spirocyclohexane oxindoles bearing six contiguous stereocenters in good yields (up to 85%) and with excellent stereoselectivities (>20 : 1 dr, >99% ee).

• 出版日期2015
• 单位复旦大学