Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI

作者：Frosini Daniela; Ceravolo Roberto; Tosetti Michela; Bonuccelli Ubaldo; Cosottini Mirco^*

来源：Journal of Neural Transmission, 2016, 123(5): 509-513.

DOI：10.1007/s00702-016-1529-2

• Corticobasal degeneration
• Magnetic resonance imaging
• Multiple system atrophy
• Parkinson's disease/parkinsonism
• Progressive supranuclear palsy

Ten healthy subjects (HS) and 15 patients with atypical parkinsonisms underwent 7-T susceptibility-weighted-imaging MR to evaluate substantia nigra (SN). All HS were judged "normal". Twelve out of 15 patients exhibited bilateral abnormal SN while three patients with corticobasal degeneration (CBD) showed bilateral normal aspect of SN. Anatomical changes of SN at 7 T occur in multiple system atrophy and progressive supranuclear palsy as previously reported in Parkinson's disease. Preserved SN in CBD confirms the pathological heterogeneity of this disease.

• 出版日期2016-5