A novel and efficient synthesis of pyrazolo[3,4-d]pyrimidine derivatives and the study of their anti-bacterial activity

作者：Rostamizadeh Shahnaz^*; Nojavan Masoomeh; Aryan Reza; Sadeghian Hamid; Davoodnejad Mandieh

来源：Chinese Chemical Letters, 2013, 24(7): 629-632.

DOI：10.1016/j.cclet.2013.04.035

• Pyrazolo[3,4-d]pyrimidine derivatives
• Pyrimidine-5-carbonitrile derivatives
• Antibacterial activity
• Staphylococcus aureus
• Enterococcus raffinosus

In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot, three-component reaction of an aldehyde, malononitrile and benzamidine hydrochloride, in the presence of magnetic nano Fe3O4 particles as a catalyst under solvent-free conditions. 3-Amino-6-aryl-2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydrazine hydrate and their antibacterial activity has been evaluated.

• 出版日期2013-7