Health-related quality of life in depression: A STAR*D report

作者：Daly Ella J; Trivedi Madhukar H^*; Wisniewski Stephen R; Nierenberg Andrew A; Gaynes Bradley N; Warden Diane; Morris David W; Luther James F; Farabaugh Amy; Cook Ian; Rush A John

来源：Annals of Clinical Psychiatry, 2010, 22(1): 43-55.

• Health-related quality of life
• major depressive disorder
• domains of quality of life

BACKGROUND: Although major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQOL), few studies have evaluated HRQOL dysfunction in multiple domains. This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
METHODS: The relationship of HRQOL, and baseline sociodemographic and clinical features, including depressive severity, was evaluated. We assessed HRQOL with the 12-item Short Form Health Survey, the 5-item Work and Social Adjustment Scale, and the 16-item Quality of Life Enjoyment and Satisfaction Questionnaire.
RESULTS: Among 2307 participants, greater depressive symptom severity was associated with poorer HRQOL. After controlling for age and depression severity, lower HRQOL was related independently to being African American or Hispanic, less educated, unemployed, divorced or separated, having public medical insurance, and to having more general medical disorders. We found impairments across all 3 domains, with low correlations between the 3 measures of HRQOL chosen, suggesting that they evaluate different and nonoverlapping aspects of function.
CONCLUSION: Sociodemographically disadvantaged patients with greater general medical and depressive illness burden are at greatest risk for poorer quality of life. Distinct impairments are seen in the 3 domains of HRQOL.

• 出版日期2010-2