Apolipoprotein B as an independent predictor of arterial stiffness in systemic lupus erythematosus patients

作者：Kwankaew Jirateep^*; Leelawattana Rattana; Saignam Anchalee; Siripaitoon Boonjing; Uea Areewongsa Parichat; Juthong Siri****

来源：International Journal of Rheumatic Diseases, 2015, 18(4): 447-451.

DOI：10.1111/1756-185X.12384

• apolipoprotein-B
• arterial stiffness
• brachial-ankle pulse wave velocity
• lipid profile
• systemic lupus erythematosus

AimTo determine the relationship of apolipoprotein B (Apo-B) and arterial stiffness determined by brachial-ankle pulse wave velocity (baPWV) in systemic lupus erythematosus (SLE) subjects.
MethodsEighty-seven Thai SLE subjects with inactive disease activity were studied. Fasting blood was collected for creatinine, glucose, lipid profiles, Apo-B and Apo-A1. Pearson correlation and stepwise-linear regression were used for the analysis.
ResultsThe mean age of the subjects was 36.6910.85years; 6.90% of them had stage 3 or more severe chronic kidney disease, 49.40% took anti-hypertensive drugs and 4.60% had abnormal glucose metabolism. The mean value for baPWV was 1332 +/- 274.12cm/s. Thirty-six percent of the subjects had increased arterial stiffness with mean Apo-B levels of 1.05 +/- 0.31g/L compared to 0.94 +/- 0.24 in normal arterial stiffness. There were correlations of baPWV with age, systolic blood pressure (BP), diastolic BP and creatinine clearance. Apo-B tended to be associated with baPWV (P=0.06) whereas low-density lipoprotein cholesterol did not (P=0.2). By multiple regression analysis, systolic BP, age and Apo-B were the significant predictors of baPWV.
ConclusionApo-B was independently associated with arterial stiffness in SLE subjects.

• 出版日期2015-5