Antiglioma pseurotin A from marine Bacillus sp FS8D regulating tumour metabolic enzymes

作者：Anjum, Komal; Bi, Hongyun; Chai, Weiyun; Lian, Xiao-Yuan^*; Zhang, Zhizhen^*

来源：Natural Product Research, 2018, 32(11): 1353-1356.

DOI：10.1080/14786419.2017.1343329

• Bacillus sp
• FS8D
• pseurotin A
• antiglioma activity
• tumour metabolic enzymes

Pseurotin A was isolated from a culture of marine Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3M. It has been found that pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation. The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A. @@@ [GRAPHICS]

• 出版日期2018
• 单位浙江大学