An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-dihydro-1,2,4-oxadiazoles

作者：Chavan Neelam L; Naik Nilesh H; Nayak Sandip K; Kusurkar Radhika S^*

来源：ARKIVOC, 2010, 248-255.

• N-aryl amidines
• 4,5-dihydro-1,2,4-oxadiazoles
• hydrogenolysis
• Nitrile oxides
• 1,3-dipolar cycloaddition reaction

4,5-Dihydro-1,2,4-oxadiazoles were prepared using 1,3-dipolar cycloaddition of imines with nitrile oxides. Further reductive N-O bond cleavage furnished monosubstituted N-aryl amidines in good yield. Thus an efficient route for the synthesis of monosubstituted N-aryl amidines has been developed.

• 出版日期2010