Antitumor effect of sonodynamically activated pyrrolidine tris-acid fullerene

作者：Iwase Yumiko; Nishi Koji; Fujimori Junya; Fukai Toshio; Yumita Nagahiko^*; Ikeda Toshihiko; Chen Fu shin; Momose Yasunori; Umemura Shin ichiro

来源：Japanese Journal of Applied Physics, 2016, 55(7): 07KF02.

DOI：10.7567/JJAP.55.07KF02

In this study, the sonodynamically induced antitumor effect of pyrrolidine tris-acid fullerene (PTF) was investigated. Sonodynamically induced antitumor effects of PTF by focused ultrasound were investigated using isolated sarcoma-180 cells and mice bearing ectopically-implanted colon 26 carcinoma. Cell damage induced by ultrasonic exposure was enhanced by 5-fold in the presence of 80 mu M PTF. The combined treatment of ultrasound and PTF suppressed the growth of the implanted colon 26 carcinoma. Ultrasonically induced 2,2,6,6-tetramethyl-4-piperidone-1-oxyl (4oxoTEMPO) production in the presence and absence of PTF was assessed, and it was shown that 80 mu M PTF enhanced 4oxoTEMPO production as measured by ESR spectroscopy. Histidine, a reactive oxygen scavenger, significantly reduced cell damage and 4oxoTEMPO generation caused by ultrasonic exposure in the presence of PTF. These results suggest that singlet oxygen is likely to be involved in the ultrasonically induced cell damage enhanced by PTF.

• 出版日期2016-7
• 单位东华大学