Antiplasmodial Activity of Compounds from the Surface Exudates of Senecio roseiflorus

作者：Kerubo Leonidah Omosa; Midiwo Jacob Ogweno; Derese Solomon; Langat Moses K^*; Akala Hosea M; Waters Norman C; Peter Martin; Heydenreich Matthias

来源：Natural Product Communications, 2013, 8(2): 175-176.

• Senecio roseiflorus
• Asteraceae
• Surface exudates
• Antiplasmodial activity

From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4%26apos;-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 mu g/mL respectively.

• 出版日期2013-2