Activation of the ERK1/2 Mitogen-Activated Protein Kinase Cascade by Dentin Matrix Protein 1 Promotes Osteoblast Differentiation

作者：Eapen Asha; Ramachandran Amsaveni; Pratap Jitesh; George Anne^*

来源：Cells Tissues Organs, 2011, 194(2-4): 255-260.

DOI：10.1159/000324258

• Dentin matrix protein 1
• ERK1/2 MAP kinase
• Runx2
• RGD
• Osteoblast differentiation

DMP1 has been shown to play many roles in osteogenesis. We recently demonstrated that calcium-mediated stress kinase activation by DMP1 leads to osteoblast differentiation. In this study we demonstrate that DMP1 can also activate the extracellular signal-regulated kinase (ERK)-MAPK pathway. This activation was mediated through the RGD integrin-binding domain in DMP1. Further, we demonstrate that Runx2, an essential transcription factor, is stimulated by the ERK-MAPK pathway.

• 出版日期2011