An efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation using a heterogeneous catalyst under solvent-free conditions

作者：Maheswara M; Siddaiah V; Damu GLV; Rao CV^*

来源：Arkivoc, 2006, 201-206.

• HClO4-SiO2
• Hantzsch condensation
• one-pot synthesis
• polyhydroquinoline derivatives

An efficient Hantzsch condensation of polyhydroquinoline derivatives was reported via a four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of HClO4-SiO2 under solvent-free conditions. Operational simplicity, use of an economically convenient catalyst, high yield, short reaction times are the key features of this protocol.

• 出版日期2006