Antimutagenic effect of curcumin and its effect on the immune response in mice

作者：Smerak P^*; Polivkova Z; Sestakova H; Stetina R; Barta I; Langova M; Turek B; Bartova J

来源：Czech Journal of Food Sciences, 2006, 24(2): 72-83.

• curcumin
• antimutagenic effects
• response of immune
• Ames test
• micronucleus test
• comet assay
• chemiluminescence
• blastic transformation tests

A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities. Among the most extensively investigated and well-defined dietary chemopreventives is curcumin. Using the Ames test and ill vivo micronucleus test, chemiluminescence test, blastic transformation test, and comet assay, we examined the antimutagenic effects of the chemically identified chemoprotective substance curcumin (diferuloylmethane) in the pure form on mutagenicity induced by three reference mutagens: aflatoxin B-1 (AFB(1)), 2-amino-3-metylimidazo [4,5-f]quinoline (IQ), and N-nitroso-N-metylurea (MNU), and the effect of curcumin on the immunosuppression caused by these mutagens. Curcumin in the pure form showed a clear antimutagenic and immunomodulatory activities on mutagenicity and immunosuppression induced by reference mutagens.

• 出版日期2006