Nanoparticles featuring amino acid-functionalized side chains as DNA receptors

作者：Ghosh Partha S; Han Gang; Erdogan Belma; Rosado Olga; Krovi Sai Archana; Rotello Vincent M^*

来源：Chemical Biology & Drug Design, 2007, 70(1): 13-18.

DOI：10.1111/j.1747-0285.2007.00534.x

• amino acid
• DNA
• nanoparticle

A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.

• 出版日期2007-7