Assessment of choroidal thickness before and after steep Trendelenburg position using swept-source optical coherence tomography

作者：Rim Tyler Hyungtaek; Lee Christopher Seungkyu; Kim Kangyoon; Kim Sung Soo^*

来源：British Journal of Ophthalmology, 2015, 99(4): 493-499.

DOI：10.1136/bjophthalmol-2014-305525

Background To evaluate changes in choroidal thickness before and after steep Trendelenburg position (SIP, 40 head-down) using automated segmentation software to analyse swept-source optical coherence tomography (SS-OCT) data.
Methods The eyes of 20 healthy volunteers underwent a three-dimensional wide scanning protocol with SS-OCT (Topcon, Tokyo, Japan) at baseline, immediately after STP was initiated, and 5, 10 and 15 min after SIP; blood pressure and heart rate were measured concurrently. The predictive mean difference was calculated using a generalised linear mixed model that adjusted for potential confounders.
Results Mean choroidal thickness significantly and transiently increased immediately (268.18 +/- 9.24 p<0.01) and 5 min (264.25 +/- 9.30 mu m, p=0.03) after SIP, relative to baseline (256.51 +/- 9.20 mu m). However, choroidal thickness decreased by 10 min (262.51 +/- 9.34 mu m, p=0.15) and 15 min (261.38 +/- 9.40 p=0.37) after SIP. Mean arterial pressure also transiently increased from baseline (78.2 +/- 1.2 mm Hg) immediately after SIP (79.9 +/- 1.1 mm Hg, p=0.01), but normalised by 5 min after SIP (p>0.05 for all comparisons >= 5 min).
Conclusions Choroidal thickness significantly but transiently increases after adopting SIP, as evaluated by automated layer segmentation analysis of SS-OCT data.

• 出版日期2015-4