Muscle contraction mechanism based on single molecule measurements

作者：Yanagida Toshio; Ishii Yoshiharu^*

来源：Journal of Muscle Research and Cell Motility, 2012, 33(6): 395-402.

DOI：10.1007/s10974-012-9332-7

• Muscle contraction
• Single molecule measurements
• Brownian movement
• Muscle model
• Flashing ratchet model

Single molecule measurements have shown that a muscle myosin step is driven by biased Brownian movement. Furthermore, they have also demonstrated that in response to strain in the backward direction a detached myosin head preferentially attaches to the forward direction due to an accelerated transition from a weak binding to strong binding state. Because they are consistent with the original Huxley model for muscle contraction, we have built a model that describes macroscopic muscle characteristics based on these single molecule results.

• 出版日期2012-12