Non-HDL cholesterol vs. Apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study

作者：Sondermeijer Brigitte M; Rana Jamal S; Arsenault Benoit J; Shah Prediman K; Kastelein John J P; Wareham Nicholas J; Boekholdt S Matthijs^*; Khaw Kay Tee

来源：European Journal of Clinical Investigation, 2013, 43(10): 1009-1015.

DOI：10.1111/eci.12129

• Apolipoprotein B
• coronary heart disease
• low-density lipoprotein cholesterol
• non-high-density lipoprotein cholesterol

Background There is an ongoing debate about the performance of non-high-density lipoprotein cholesterol (non-HDL-C) compared with apolipoprotein B (apo B) in the prediction of coronary heart disease (CHD) risk. Therefore, we compared the associations between non-HDL-C and apo B in regard to CHD among apparently healthy Western European individuals. %26lt;br%26gt;Design In the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk prospective population study, 25639 men and women aged 45-79years were followed for 11428years. Those with diabetes or prevalent CHD at baseline were excluded. A total of 2066 (121%) participants developed CHD during 195692 person-years follow-up. %26lt;br%26gt;Results The multivariable-adjusted hazard ratio [HR] of future CHD per one standard deviation increase was 122 [95% confidence interval (CI): 117-127] for LDL-C, 126 (95% CI 120-131) for non-HDL-C and 119 (95% CI 114-124) for apo B, respectively. The multivariable-adjusted HR of future CHD in the highest quartile LDL-C was 167 (95% CI: 147-191). For non-HDL-C and apo B, these respective HRs were 187 (95% CI: 162-215) and 156 (95% CI: 136-178). Kaplan-Meier survival analyses showed that there was incremental and comparable increase in risk of CHD with increasing quartiles of both non-HDL-C and apo B. %26lt;br%26gt;Conclusions In this prospective study, non-HDL-C and apo B were comparable in their ability to predict risk of future CHD.

• 出版日期2013-10