Association between Cystatin C and Arteriosclerosis in the Absence of Chronic Kidney Disease

作者：Yamashita Hiroshi; Nishino Tomoya^*; Obata Yoko; Nakazato Mio; Inoue Keita; Furusu Akira; Takamura Noboru; Maeda Takahiro; Ozono Yoshiyuki; Kohno Shigeru

来源：Journal of Atherosclerosis and Thrombosis, 2013, 20(6): 548-556.

DOI：10.5551/jat.13193

• Cystatin C
• Cardiovascular disease
• Cardio-ankle vascular index (CAVI)
• Carotid intima-media thickness (CIMT)

Aim: Chronic kidney disease (CKD) is a known risk factor for cardiovascular disease (CVD). Cystatin C was recently reported to be an endogenous surrogate of kidney function, and a high level of cystatin C is reported to be a strong predictor of CVD; however, the association between cystatin C and arteriosclerosis in a non-CKD population is unclear. This study aimed to clarify the association between cystatin C and arteriosclerosis in a non-CKD population. %26lt;br%26gt;Methods: Of the 637 Japanese adults (264 men, 373 women) enrolled, we analyzed 446 participants with an estimated glomerular filtration rate (eGFR) %26gt; 60 mL/min and no proteinuria (177 men, 269 women) without a history of CVD. Kidney function was evaluated according to serum cystatin C levels and eGFR. Arteriosclerosis was evaluated on the basis of the cardio-ankle vascular index (CAVI) and carotid intima-media thickness (CIMT). %26lt;br%26gt;Results: The mean age of our subjects was 67.0 +/- 10.0 years. No variables showed any significant differences according to gender. The results of multiple linear regression analysis showed a significant correlation between serum cystatin C and CAVI only in women, but not CIMT. %26lt;br%26gt;Conclusion: We observed a significant correlation between cystatin C and CAVI, which is a marker of early-stage arteriosclerosis, in women in a non-CKD population with no proteinuria and eGFR %26gt; 60 mL/min.

• 出版日期2013