A Water-Soluble Polycarbonate With Dimethylamino Pendant Groups Prepared by Enzyme-Catalyzed Ring-Opening Polymerization

作者：Zhang Xiaojin; Cai Mengmeng; Zhong Zhenlin^*; Zhuo Renxi

来源：Macromolecular Rapid Communications, 2012, 33(8): 693-697.

DOI：10.1002/marc.201100765

• aliphatic polycarbonates
• degradation
• enzyme catalyst
• ring-opening polymerization
• water-soluble polymers

A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)2 as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.

• 出版日期2012-4-23
• 单位武汉大学