AMBROXOL INHIBITS NEUTROPHIL RESPIRATORY BURST ACTIVATED BY ALPHA CHAIN INTEGRIN ADHESION

作者：Peroni D G; Moser S; Gallo G; Pigozzi R; Tenero L; Zanoni L; Boner A L; Piacentini G L^*

来源：International Journal of Immunopathology and Pharmacology, 2013, 26(4): 883-887.

DOI：10.1177/039463201302600406

• oxidative stress
• ambroxol
• neutrophils
• integrins

The purpose of the present study was to investigate the possible anti-oxidant effect(s) of Ambroxol on neutrophils activated by ligand-binding of the drug with membrane-associated adhesion integrin CD11a and to estimate dose-response changes in oxygen free radical production. The amount of free radical production by anti-CD11a- and anti-CD4-coated neutrophils stimulated with N-formyl-methionylleucyl-phenylalanine (FMLP) and challenged with increasing concentration of Ambroxol, was evaluated within a time frame of 90 minutes. A significant dose-dependent effect response of Ambroxol on O-2(-) production by cells coated with anti-CD11a antibody was observed. This preliminary study opens a new perspective on the therapeutic role of Ambroxol as an antioxidant drug and for its potential use in controlling oxidative stress, particularly in leukocyte-dependent inflammation.

• 出版日期2013-12