A Unique Expression Pattern of Tbx10 in the Hindbrain as Revealed by Tbx10(lacZ) Allele

作者：Xue Xiao Dong; Kimura Wataru; Wang Bo; Hikosaka Keisuke; Itakura Tatsuo; Uezato Tadayoshi; Matsuda Masashi; Koseki Haruhiko; Miura Naoyuki^*

来源：Genesis, 2010, 48(5): 295-302.

DOI：10.1002/dvg.20615

• Tbx10
• interneuron
• rhombomere
• pons

To study the expression/function of Tbx10, a T-box gene, Tbx10(LacZ/+) mice were established by replacing the T-box coding region with a LacZ gene. X-gal staining showed that LacZ(+) cells were localized to two-cell populations in rhombomere 4 and rhombomere 6. No significant differences in the locations of LacZ(+) cells were found between Tbx10(LacZ/+) and Tbx10(LacZ/LacZ) mice, and the Tbx10(Lacz/LacZ) mice were viable and fertile. We found that the LacZ(+) cells are present in both embryonic and adult mice. Histological studies suggest that the rhombomere 4-derived LacZ(+) cells are a subpopulation of the ventral interneurons in the pons. genesis 48:295-302, 2010.

• 出版日期2010-5
• 单位RIKEN