Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day

作者：Kwak Han Deok^*; Choi Dong Jin; Woo Si Uk; Kim Jin; Urn Jun Won; Kim Seon Hahn

来源：Journal of the Korean Surgical Society, 2010, 78(6): 385-389.

DOI：10.4174/jkss.2010.78.6.385

• Antimicrobial prophylaxis
• Monotherapy
• Laparoscopic colorectal surgery
• Surgical site infection
• Hospital acquired infection

Purpose: We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection.
Methods: The patients undenvent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection.
Results: The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456).
Conclusion: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection. (J Korean Surg Soc 2010;78:385-389)

• 出版日期2010-6