A bilayered PLGA/multiwall carbon nanotubes/bacterial cellulose composite membrane for tissue regeneration of maxillary canine periodontal bone defects

作者：Zhang, Hualin^*; Wang, Juan; Wang, Kairong; Xu, Lihua^*

来源：Materials Letters, 2018, 212: 118-121.

DOI：10.1016/j.matlet.2017.10.058

• PLGA
• Carbon nanotubes
• Bacterial cellulose
• Composite materials
• GTR membrane

A bilayered polylactic-co-glycolic acid (PLGA)/multiwall carbon nanotubes (MWNTs)/bacterial cellulose (BC) composite membrane was prepared by vacuum freeze-drying and electrospinning for use as a guided tissue regeneration (GTR) membrane to repair maxillary canine periodontal defects in beagle dogs. Morphological and histological observations and analyses were performed to characterize the membrane. The bilayered membrane comprised a lower fibrous BC film layer and an upper electrospun PLGA/MWNTs film layer with a three-dimensional network structure. The histological results showed that the bilayered membrane promoted periodontal tissue regeneration. The BC/PLGA/MWNTs membrane may be an ideal GTR membrane candidate and thus has potential therapeutic applications in periodontal disease.

• 出版日期2018-2-1
• 单位宁夏医科大学; 温州医科大学