Antimicrobial evaluation of 1,4-benzoxazine derivatives

作者：Pamerla Muralidhar; Reddy D Rama Sekhara; Rao B Sreenivasa; Bodipati Naganjaneyulu^*; Murthy Y L N

来源：Medicinal Chemistry Research, 2015, 24(2): 611-615.

DOI：10.1007/s00044-014-1159-x

• Benzoxazine
• Antibacterial
• Disc diffusion method
• Minimum inhibitory concentration
• In vitro

In this study, a series of N-unprotected 1,4-benzoxazine derivatives were evaluated for antibacterial activity. All the compounds showed low to good activity against Gram-positive and Gram-negative bacteria. Benzoxazine derivatives bearing nitro and trifluoromethyl groups are more potent than the other ones. Compounds with cyanide and ester groups have displayed poor activity. The compound 1c has shown good activity against Gram-positive as well as Gram-negative bacteria.

• 出版日期2015-2