Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

作者：Grasa Lopez Ameyalli; Miliar Garcia Angel; Quevedo Corona Lucia; Paniagua Castro Norma; Escalona Cardoso Gerardo; Reyes Maldonado Elba; Jaramillo Flores Maria Eugenia

来源：Marine Drugs, 2016, 14(8): 148.

DOI：10.3390/md14080148

• fucoxanthin
• Undaria pinnatifida
• obesity
• inflammation
• energy expenditure
• adipose tissue expansion
• gene expression

Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, beta-oxidation and adipogenesis by upregulating PPAR alpha, PGC1 alpha, PPAR gamma and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.

• 出版日期2016-8