A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

作者：Wang Zhan Chang; Lin Yi Ming^*; Feng Dan Qin; Ke Cai Huan; Lin Peng; Yan Chong Ling; De Chen Jun

来源：Molecules, 2009, 14(1): 414-422.

DOI：10.3390/molecules14010414

• Diterpenes
• Biofilm
• Excoecaria agallocha
• Anti-microfouling

A new atisane-type diterpene, ent-16 alpha-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16 alpha-hydroxy-atisane-3-one (1), ent-atisane-3 beta, 16 alpha-diol (2), ent-3,4-seco-16 alpha-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54 /- 0.01 ppm.

• 出版日期2009-1
• 单位厦门大学