科研之友
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摘要
GGPPS is a member of prenyl transferase family catalyzing the synthesis of GGPP (Geranylgeranyl diphosphate) from Famesyl diphosphate (FPP) and Isopentenyl diphosphate (IPP) Using cre/loxp system, researchers got oocyte specific knockout ggpps mice Mutation of ggpps resulted m abnormality of follicular development, granulosa cell premature luternization, theca cell hypertrophy and multi-oocyte follicles Interaction of oocyte and granulosa cell was also changed Oocyte-specific knockout of ggpps mice was acquired Follicles grew abnormally m ggpps mutation mice Interaction of oocyte and granulosa cell was also changed
