First asymmetric total synthesis of novel and cytotoxic 2 '-R-hydroxylanneaquinol

作者：Suresh V; Rajesh K; Selvam J Jon Paul; Venkateswarlu Y^*

来源：Tetrahedron Letters, 2008, 49(52): 7358-7360.

DOI：10.1016/j.tetlet.2008.09.076

• 2 '-R-Hydroxylanneaquinol
• Jacobsen's resolution
• Asymmetric synthesis

A novel cytotoxic alkylated hydroquinone 2'-R-hydroxylanneaquinol (1), isolated from the organic extract of the plant Lannea welwitschii, has been synthesized for the first time using commercially available 4-methoxyphenol. The key step of this process involves the kinetic resolution of epoxide 6 using Jacobsen's reaction conditions.

• 出版日期2008-12-22