Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

作者：Correia Sonia C; Perry George; Moreira Paula I^*

来源：Biochimica et Biophysica Acta-Molecular Basis of Disease, 2016, 1862(10): 1909-1917.

DOI：10.1016/j.bbadis.2016.07.010

• Alzheimer's disease
• Mitochondrial bioenergetics
• Mitochondrial dynamics
• Mitochondrial transport
• Amyloid-beta
• Tau
• Synapse

The vigorous axonal transport of mitochondria, which serves to distribute these organelles in a dynamic and non-uniform fashion, is crucial to fulfill neuronal energetic requirements allowing the maintenance of neurons structure and function. Particularly, axonal transport of mitochondria and their spatial distribution among the synapses are directly correlated with synaptic activity and integrity. Despite the basis of Alzheimer's disease (AD) remains enigmatic, axonal pathology and synaptic dysfunction occur prior the occurrence of amyloid-beta (A beta) deposition and tau aggregation, the two classical hallmarks of this devastating neurodegenerative disease. Importantly, the early stages of AD are marked by defects on axonal transport of mitochondria as denoted by the abnormal accumulation of mitochondria within large swellings along dystrophic and degenerating neuritis. Within this scenario, this review is devoted to identify the molecular "roadblocks" underlying the abnormal axonal transport of mitochondria and consequent synaptic "starvation" and neuronal degeneration in AD. Understanding the molecular nature of defective mitochondrial transport may provide a new avenue to counteract AD pathology.

• 出版日期2016-10