Major essential oils composition and immunotoxicity activity from leaves of Foeniculum vulgare against Aedes aegypti L

作者：Chung Ill Min; Ro Hee Myong; Moon Huyng In^*

来源：Immunopharmacology and Immunotoxicology, 2011, 33(3): 450-453.

DOI：10.3109/08923973.2010.532805

• Aedes aegypti
• Foeniculum vulgare
• essential oils
• immunotoxicity effects
• fenchone
• (E)-anethole
• Umbelliferae

The leaves of Foeniculum vulgare (Umbelliferae) were extracted and the major essential oil composition and immunotoxicity effects were studied. The analyses conducted by gas chromatography and mass spectroscopy (GC-MS) revealed the essential oils of F. vulgare leaves. The F. vulgare essential oil yield was 0.97%, and GC/MS analysis revealed that its major constituents were methyl clavicol (46.3%), a-phellandrene (18.2%), fenchone (10.6%), (E)-anethole (11.3%), myrcene (3.4%), and alpha-pinene (2.1%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 41.23 ppm and an LC(90) value of 65.24 ppm. Also, methyl clavicol (>= 98.0%), alpha-phellandrene (>= 95.0%), fenchone (>= 98.0%), (E)-anethole (>= 99.0%), myrcene (>= 99.0%), and a-pinene (>= 99.0%) were tested against the F(21) laboratory strain of A. aegypti. Fenchone (>= 98.0%) and (E)-anethole (>= 99.0%) have medium activity with an LC(50) value of 73.11 ppm and 102.41 ppm. The above data indicate that major compounds interaction may play a more important role in the toxicity of essential oil.

• 出版日期2011-9