Comparison of Donor Sources in Hematopoietic Stem Cell Transplantation for Childhood Acute Leukemia: A Nationwide Retrospective Study

作者：Sakaguchi Hirotoshi^*; Watanabe Nobuhiro; Matsumoto Kimikazu; Yabe Hiromasa; Kato Shunichi; Ogawa Atsushi; Inagaki Jiro; Goto Hiroaki; Koh Katsuyoshi; Yoshida Nao; Kato Keisuke; Cho Yuko; Kosaka Yoshiyuki; Takahashi Yoshiyuki; Inoue Masami; Kato Koji; Atsuta Yoshiko; Miyamura Koichi

来源：Biology of Blood and Marrow Transplantation, 2016, 22(12): 2226-2234.

DOI：10.1016/j.bbmt.2016.09.020

• Childhood acute leukemia
• Alternative donor
• Nationwide study

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the best therapeutic option for childhood high-risk acute leukemia. However, which donor source is optimal for children lacking an identical sibling remains unclear. To evaluate the clinical impact of donor source on allo-HSCT in childhood acute leukemia, we analyzed data from 577 children who underwent allo-HSCT after a myeloablative regimen during first or second complete remission from 2005 to 2012, using registry data of the Japan Society for Hematopoietic Cell Transplantation, and we compared outcomes of 7/8 to 8/8 HLA allelic-matched unrelated bone marrow transplantation (UR-BMT, n = 218) and 4/6 to 6/6 HLA allelic-matched unrelated cord blood transplantation (URCBT, n = 200) to those of HLA-identical related bone marrow transplantation (ID-BMT, n = 159). The median follow-up of survivors was 40.0 months. Three-year overall survival (OS) and leukemia-free survival (LFS) rates for ID-BMT, UR-BMT, and UR-CBT were 74.8% and 69.0%, 75.0% and 69.6%, and 71.8% and 63.8%, respectively. The multivariate analysis demonstrated that OS and LFS for the 3 groups are comparable, although UR-CBT carries a greater risk of nonrelapse mortality (hazard ratio, 2.20; P=.03, compared to ID-BMT) in the myeloablative setting for childhood high-risk acute leukemia.

• 出版日期2016-12