Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells

作者：Patil Rajeshwari H; Babu R L; Kumar M Naveen; Kumar K M Kiran; Hegde Shubha M; Nagesh Rashmi; Ramesh Govindarajan T; Sharma S Chidananda^*

来源：Inflammation, 2016, 39(1): 138-147.

DOI：10.1007/s10753-015-0232-z

• apigenin
• LPS
• pro-inflammatory mediators
• AP-1 factors
• A549

Apigenin is one of the plant flavonoids present in fruits and vegetables, acting as an important nutraceutical component. It is recognized as a potential antioxidant, antimicrobial, and anti-inflammatory molecule. In the present study, the mechanism of anti-inflammatory action of apigenin on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and activator protein-1 (AP-1) factors in human lung A549 cells was investigated. The antiaEuroinflammatory activity of apigenin on LPS-induced inflammation was determined by analyzing the expression of pro-inflammatory cytokines, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and different AP-1 factors. Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1 beta, IL-2, IL-6, IL-8, and TNF-alpha), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production. Study confirms the anti-inflammatory effect of apigenin by inhibiting the expression of inflammatory mediators and AP-1 factors involved in the inflammation and its importance in the treatment of lung inflammatory diseases.

• 出版日期2016-2