Binding abilities of copper to phospholipids and transport of oxalate

作者：Dytrtova Jana Jaklova; Jakl Michal; Novakova Katerina; Navratil Tomas^*; Sadek Vojtech

来源：Monatshefte fur Chemie, 2015, 146(5): 831-837.

DOI：10.1007/s00706-014-1385-4

• Copper cations
• Dipalmitoylphosphatidylcholine (lecithin)
• ESI-MS
• Impedance spectroscopy
• Oxalic acid
• Voltammetry
• Membrane

Cu(II) creates complexes with dipalmitoylphosphatidylcholine (lecithin), which are detectable using electrospray ionization mass spectrometry. Lecithin (L) as a relatively big ligand prevents Cu(II) reduction to Cu(I) during the electrospray process. The detected complexes include (1) dications with a general formula: [Cu(L) (n) ](2+), where n prevails from 2 to 5 (in the m/z range from 50 to 2,000); and (2) monocations originated from the metal salt precursor [CuCl(L) (k) ](+) (k is 1 or 2). The Cu(II)/lecithin complexes are stable enough (appearance energy higher than 200 kJ mol(-1)) to utilize Cu(II) for stabilization of an artificial membrane. The impermeability of an artificial phospholipid membrane for oxalic acid and its complexes with copper ions in slightly acidic pH 5 was confirmed voltammetrically. However, adsorption of copper-oxalate complexes on the membrane surface was proved using electrochemical impedance spectroscopy.
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• 出版日期2015-5