A Novel ER Stress-Independent Function of the UPR in Angiogenesis

作者：Urra Hery; Hetz Claudio^*

来源：Molecular Cell, 2014, 54(4): 542-544.

DOI：10.1016/j.molcel.2014.05.013

Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is independent of endoplasmic reticulum (ER) stress, mediated by mTOR signaling to promote endothelial cell survival and angiogenesis.

• 出版日期2014-5-22