A case of spontaneous regression of small cell lung cancer with progression of paraneoplastic sensory neuropathy

作者：Hirano Satoshi^*; Nakajima Yoshifumi; Morino Eriko; Fujikura Yuji; Mochizuki Makoto; Takeda Yuichiro; Sugiyama Haruhito; Kobayashi Nobuyuki; Tanaka Keiko; Kudo Koichiro

来源：Lung Cancer, 2007, 58(2): 291-295.

DOI：10.1016/j.lungcan.2007.05.005

• spontaneous regression
• small cell lung cancer (SCLC)
• paraneoplastic sensory neuropathy (PSN)
• paraneoplastic syndrome
• atypical antineuronal antibody

We report here a rare case of small cell lung cancer (SCLC) accompanied by a partial spontaneous regression with a progression of paraneoplastic sensory neuropathy (PSN). A 55-year-old woman was admitted to our hospital with dry cough and progressive numbness in the distal extremities over 1 month. She was diagnosed as small cell lung cancer associated with paraneoplastic sensory neuropathy. About 1 month later, partial spontaneous regression of tumor with a progression of paraneoplastic sensory neuropathy was observed. A complete response was achieved through chemotherapy and concurrent radiotherapy. As the tumor size decreased, her neurological symptoms improved. A short interval between onset of PSN and the start of therapy may be essential for successful treatment for not only SCLC but also PSN.

• 出版日期2007-11