Clinical significance of decreased protein expression of dehydroepiandrosterone sulfate in the development of depression: A meta-analysis

作者：Hu, Qiang^*; Zhang, Sheng-Yu; Liu, Fei; Zhang, Yan-Li; Zhu, Dian-Ming; Zang, Yin-Yin

来源：Journal of Affective Disorders, 2015, 174: 416-423.

DOI：10.1016/j.jad.2014.11.051

• Dehydroepiandrosterone sulfate protein
• Depression
• Meta-analysis

Background: Previous evidence has shown that adrenal androgens, dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) have significant functions related to the control of mood, affect, and anxiety. Changes in their expression levels are reportedly relatert to several psychiatric disorders. The objective of this meta-analysis was to explore the role of DHEAS protein expression in patients with depression. @@@ Method: Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM) and China National Knowledge Infrastructure (CNKI) were electronically searched. Only those studies that analyzing DHEAS expression in depression patients were considered eligible for inclusion. Standardized mean differences (SMDs) were pooled with a 95% confidence interval (Cl) in accordance with the random effects model. @@@ Results: Ten clinical case control studies, consisting of 4496 subjects (493 patients with depression and 4003 healthy controls) were incorporated for analysis. Results revealed a lower DHEAS protein expression level in patients with depression than in normal controls (SMD=0.17, 95% Cl : 0.06-027, P=0.002). Ethnicity-stratified analysis indicated that lower levels of DHEAS expression in depression patients were not observed in Caucasians or Asians (both P > 0.05), @@@ Conclusion: Elevated DHEAS protein expression may be correlated with the biological pathophysiology of depression, indicating that checking DHEAS levels and administration of DHEAS could contribute to the effective treatment of depression.

• 出版日期2015-3-15
• 单位司法部司法鉴定科学技术研究所; 上海市精神卫生中心; 同济大学