Development of an Electrochemical Sensor Based on Reduced Graphene Oxide Modified Screen-Printed Carbon Electrode for the Determination of Buprenorphine

作者：Fakhari Ali Reza^*; Sahragard Ali; Ahmar Hamid

来源：Electroanalysis, 2014, 26(11): 2474-2483.

DOI：10.1002/elan.201400196

• Buprenorphine (BN)
• Screen printed carbon electrode (SPCE)
• Reduced graphene oxide (r-GO)
• Density Functional Theory (DFT)
• Electrochemical sensor
• Modified electrodes

In this research, we have developed an electrochemical buprenorphine (BN) sensor based on reduced graphene oxide (r-GO) as an electrode modifier on the screen printed carbon electrode (SPCE) surface. BN oxidation pathway was proposed using voltammetric studies and with the aid of Density Functional Theory (DFT). The effects of various parameters including pH, modifier amount, accumulation time, and accumulation potential on the oxidation peak current of BN were optimized. Under the optimized conditions, the linear response range and the limit of detection were obtained as 0.50100 mM and 0.16 mu M (S/N=3) using differential pulse voltammetry (DPV), respectively. The selectivity of the modified electrode in the presence of potential interferences was also studied, and finally the electrode was successfully employed for the determination of BN in spiked urine samples.

• 出版日期2014-11