Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp 16-5c

作者：Huang Xishan; Huang Hongbo; Li Hanxiang; Sun Xuefeng; Huang Huarong; Lu Yongjun; Lin Yongcheng; Long Yuhua^*; She Zhigang

来源：Organic Letters, 2013, 15(4): 721-723.

DOI：10.1021/ol303549c

Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC50 value of 2.2 mu M.

• 出版日期2013-2-15
• 单位中山大学